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For dogs or cats with itchy, irritated or allergic skin.  Helps soothe and hydrate the skin.  Detangles the fur and leaves the coat soft and shiny.  

DOUXO® is the #1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs & cats with allergic dermatitis.1 


DOUXO®  S3 CALM Shampoo is for the management of itchy, irritated or allergic skin.  

DOUXO® S3 CALM Shampoo contains OPHYTRIUM™, a purified, natural ingredient from the S3 - Safe Skincare Selection.  OPHYTRIUM™ has been carefully selected for its high tolerance and simultaneous threefold action on the skin's ecosystem:

  • Helps support the skin's physical barrier for supple, hydrated skin
  • Helps support the microbial flora for healthy skin
  • Helps soothe irritated skin  

Use DOUXO® S3 CALM Mousse or DOUXO® CALM Micro-Emulsion Spray for leave-on solutions.

DOUXO® S3 CALM Shampoo and Mousse have been proven to reduce signs of Atopic Dermatitis by 58% in 21 days.2


DOUXO® S3 CALM Shampoo and Mousse are meant to be used together in a clinically proven and consumer-friendly protocol.  

Use one pump for every 4 lbs.  Double the dosage for long and/or thick fur. 

1.  Wet with cool water from the neck down

2.  Gently massage shampoo onto the problem area

3. Repeat on entire body and leave on for 10 minutes

4. Rinse with cool water until the water runs clear. 

5.  Repeat if necessary.

Cautions: For external use on dogs or cats only. Avoid contact with the eyes. In case of contact with eyes, rinse thoroughly and consult your veterinarian. If irritation occurs or increases, discontinue use and consult with your veterinarian.

Available Sizes:

  • 200 mL or 500 mL

1.  DOUXO® is the #1 non-prescription topical therapy used and recommended by U.S. veterinarians for allergic dermatitis.  BIO'SAT Quantitative Study: Dermatological products for cats and dogs among 250 U.S. Veterinary Practices. October 2018.

2.  Gatellet, M., Kesteman, R., Blondel, T., et al. (2020).  Performance of a combination of Ophytrium-containing shampoo and mousse applications in the management of sensitive skin in dogs:  intermediate results of a field study.  14th UNISVET NATIONAL CONGRESS.  Milan, Italy.


Related Products


DOUXO®  Calm helps manage pruritus and inflammation associated with allergies. It is soothing and relieving to the skin. 

DOUXO® is the #1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs and cats with allergic dermatitis.1